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Cefotaxime Sodium Salt

Cefotaxime Sodium

SKUPriceSizeQuantityAdd to Cart
CEFO001$60.891g
CEFO005$81.165g
CEFO025$364.5025g

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Chemical Formula: C16H16N5NaO7S2=477.4
CAS No.: 64485-93-4
Potency: 916 – 964μg per mg

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Cefotaxime is a β-lactam type inhibitor of bacterial cell wall synthesis. The antibiotic inhibits the crosslinking of peptidoglycan by binding and inactivating of transpeptidases. Cefotaxime Sodium has high antimicrobial activity against gram-negative bacteria. By its molecular structure, Cefotaxime Sodium is a sodium salt, and is well protected against inactivation by beta-lactamase.

Cefotaxime Sodium is often used in the treatment of severe infections, for the elimination of Agro-bacterium species after inoculation, and the growth inhibition of various bacteria, including Pectobacterium carotovorum. Cefotaxime powder is non-toxic to plant cells.

Store dry at 2-8 °C
Keep container tightly closed and protect from light
Soluble in water

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Being a producer of powdered media, Formedium Ltd has the knowledge, equipment and laboratories to produce custom made media according to the end users specifications.  If you are interested in the production of a custom made media, please complete the form below or alternatively contact us on 00 44 (0)1485 609069 or sales@formedium.com.

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CRISPR/Cas9 Mutagenesis by Translocation of Cas9 Protein Into Plant Cells via the Agrobacterium Type IV Secretion System

by DJ Schitz et al.

The research paper by explores the use of the CRISPR/Cas9 system for mutagenesis by translocating the Cas9 protein into plant cells through the Agrobacterium Type IV Secretion System (Schmitz et al., 2020). This study demonstrates the successful translocation of the Cas9 protein from Agrobacterium into yeast and plants via the T4SS, facilitated by the translocation peptide of the Agrobacterium virulence protein VirF.

In the context of this research, Cefotaxime Sodium was likely used as an antibiotic to eliminate Agrobacterium after the transfer of the CRISPR/Cas9 components into the plant cells. Cefotaxime sodium is commonly used in plant biotechnology to prevent the growth of Agrobacterium post-transformation (D’Huart et al., 2019). Cefotaxime Sodium salt is crucial to ensure that only the desired genetic modifications introduced by the CRISPR/Cas9 system remain in the plant cells, without the presence of the Agrobacterium used as a vector for gene editing.

The study showcases the innovative approach of utilizing the Agrobacterium Type IV Secretion System to deliver the Cas9 protein for genome editing in plants. By leveraging this natural mechanism, the researchers were able to achieve targeted mutagenesis efficiently. The inclusion of Cefotaxime powder in the experimental setup would have played a vital role in maintaining the integrity of the genetic modifications introduced by CRISPR/Cas9 while ensuring the elimination of Agrobacterium post-transformation.

In conclusion, the research paper highlights a novel method for CRISPR/Cas9 mutagenesis in plants through the translocation of the Cas9 protein via the Agrobacterium Type IV Secretion System. The use of Cefotaxime Sodium in this context serves as a critical component in the experimental process to enable precise genetic modifications while safeguarding against unwanted bacterial contamination.

References:

Crispr/cas9 mutagenesis by translocation of cas9 protein into plant cells via the agrobacterium type iv secretion system.
Schmitz, D., Ali, Z., Wang, C., Aljedaani, F., Hooykaas, P., Mahfouz, M., … & Pater, S. (2020).
Frontiers in Genome Editing, 2.

Physicochemical stability of cefotaxime sodium in polypropylene syringes at high concentrations for intensive care units.
D’Huart, E., Vigneron, J., Blaise, F., Charmillon, A., & Demoré, B. (2019).
Pharmaceutical Technology in Hospital Pharmacy, 4(2), 59-67.

To review our research publications library where Formedium products have been used, please view the research publications page.

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