March 2, 2021

The Cell Cycle Club provides a venue for labs working in fundamental cell cycle research in model organisms to interact with those using mammalian cells to drive research in a more ‘translational’ direction.

The meeting in March welcomes Sir Professor Paul Nurse from The Francis Crick Institute (London, UK) and recipient of the 2001 Nobel Prize in Physiology or Medicine.

Organizers:
Rob de Bruin (University College London)
John Diffley (The Francis Crick Institute)
Peter Thorpe (Queen Mary University London)

Digital Program

15:00 – 15:05 Welcome
15:05 – 15:30 Wayne Stallaert / Jeremy Purvis (University of North Carolina, US)
The molecular structure of the human cell cycle
15:30 – 15:55 Geronimo Dubra / Maarten Altelaar (CNRS, France)
CDK-mediated control of intrinsic disorder is a hallmark of the cell cycle
15:55 – 16:20 Erin Moran / Todd Stukenberg (University of Virginia, USA)
Mitotic R-loops direct Aurora 1 B kinase to maintain centromeric cohesion
16:20 – 16:40 Breakout session 1
16:40 – 17:00 Breakout session 2
17:00 – 18:00 Keynote: Sir Professor Paul Nurse (The Francis Crick Institute, UK)
Nobel Prize in Physiology or Medicine 2001 recipient
Controlling the eukaryotic cell cycle

Please note timings are shown in GMT (for local timings please see meeting website) 

16:20-16:40 – Breakout rooms for session 1

Room 1 Ana Coelho Almeida (University of Porto, Portugal) (short talk)
A mitotic screening in Indian muntjac fibroblasts reveals a role for Augmin in kinetochore fiber maturation
Room 2 Nicola Smith (University of Kent, UK) (short talk)
Potent EGF-dependent APOBEC3A induction in epithelial cells: a potential source of somatic mutation?
Room 3 Alice Finardi (European Institute of Oncology, Italy) (poster)
How to break up gracefully: Cdc5 mediates resolution and splitting
Room 4 Yolanda Moyano-Rodriguez (IBV Valencia, Spain) (short talk)
PP2A-Cdc55 phosphatase coordinates actomyosin ring contraction and septum formation during cytokinesis
Room 5 Amy Ikui (The City University of New York, USA) (short talk)
Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtii
Room 6 Ambra Dondi (European Institute of Oncology, Italy) (short talk)
Mitosis with faulty DNA: a new challenge for the cell cycle
Room 7 Hannah King (Kings College London, UK) (short talk)
Investigating the redox regulation of cyclin D-CDK4
Room 8 Anastasiya Malyshava (Imperial College London, UK) (short talk)
Synthetic Biology In Pursuit Of The Minimal Cell Cycle
Room 9 Bernardo Orr (I3S (Chromosome Instability & Dynamics Lab, Portugal) (short talk)
Protection against micronuclei formation during human cell division
Room 10 Valentina Piano (Max Planck Institute of Molecular Physiology, Germany) (short talk)
A catalytic role of CDC20 directs the timely assembly of the mitotic checkpoint complex
Room 11 Ian Jones (The Institute of Cancer Research, UK) (short talk)
G1 control only goes skin deep- A role for G2/M in melanoma size determinationPlease note timings are shown in GMT (for local timings please see meeting website) 

16:40-17:00 – Breakout rooms for session 2

Room 1 Jasmine Philip (The City University of New York, USA) (short talk)
PP2A-Cdc55 and Cdc14 dephosphorylate replication protein Cdc6 for origin licensing
Room 2 Zucca Federico (European Institute of Oncology, Italy) (short talk)
Microtubules submit to APC/C control: astrals are no exception
Room 3 Owen Chen (McGill University, Canada) (short talk)
Germline CDC20 Mutations from Familial Ovarian Germ Cell Tumours Result in Aberrant Mitotic Progression and Suggest a Cancer Predisposition Role
Room 4 Lisa Crozier (University of Dundee, Scotland) (short talk)
CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal
Room 5 Hugang Feng (The Institute of Cancer Research, UK) (short talk)
Loss of PBRM1 impairs the G2/M Checkpoint via Defective DREAM Pathway
Room 6 Robert Duster (University Clinics Bonn, Germany) (short talk)
CDK10 – initial insights from molecular biology and biochemistry
Room 7 Al-Rawi Aymen (University of Edinburgh, Scotland) (short talk)
Comprehensive phosphoproteomics demonstrates CKS1 promotes widespread phosphorylation of non-proline directed substrates by CDK1 in vitro
Room 8 Fabio Puddu (University of Cambridge, UK) (short talk)
Mutagenic mechanisms of cancer-associated DNA polymerase ε alleles
Room 9 Sara Carvalhal (University of Algarve, Portugal) (short talk)
Biallelic mutations in BUB1 affects distinct chromosome segregation pathways in patients with variegated aneuploidy
Room 10 Simon Gemble (Institute Curie, France) (short talk)
To scale or NoT tO sCaLe ”: G1 phase duration is not scaled up with DNA content in polyploid cells generating DNA damage during S phase.
Room 11 Rosemary Wilson (University of Oxford, UK) (short talk)
Sequencing DNA replication events using single molecules